Cd47 loss shifts mouse hippocampal transcriptome toward mild excitotoxic stress state
PLOS Computational Biology · Mehrdad Kiamari, Amalia Perna, Matteo Santoro, Abdel El Ariss, Eloise Berson, Jing Zhao, Chandresh R. Gajera, Edward J. Fox, Kathleen S. Montine, Nima Aghaeepour, Thomas J. Montine · Published on Readzer
Summary
A study using single-nucleus RNA sequencing of hippocampi from wild-type and Cd47 knockout mice exposed to kainic acid found that Cd47 loss shifts the hippocampal transcriptome toward a state resembling mild excitotoxic stress. The authors suggest Cd47 as a candidate regulator of neuronal stress adaptation, providing a hypothesis for further testing.
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Why it matters by industry
- Healthcare & Life Sciences
This study provides a mechanistic hypothesis linking Cd47 to neuronal stress adaptation, relevant to neuroscience and potential therapeutic targets in excitotoxicity-related conditions.